However, the 33-year-old Spaniard will not know until later on Friday whether his Herculean effort was in vain.
IMAGES from Day 4 of the French Open played at Roland Garros on Wednesday
Stefanos Tsitsipas won 6-3, 6-3, 4-6, 4-6, 6-3 to book his place in the French Open final on Friday.
Rafael Nadal's hopes of winning the year-ending ATP Finals for the first time live on after the Spaniard beat defending champion Stefanos Tsitsipas 6-4, 4-6, 6-2 on Thursday.
Novak Djokovic advanced to a record-extending 10th Australian Open final with an emphatic win over American Tommy Paul.
Sinner is most likely to upset the applecart after the Italian's run to the Canadian Open title this month
Tsitsipas, who triumphed at the Monte Carlo Country Club in the last two editions, was never in the mix against Fritz
Tsitsipas pulled out of the Wimbledon warm-up event in Halle, Germany, because of personal reasons
Top-ranked Iga Swiatek cruised past Veronika Kudermetova in the semi-final of the Madrid Open to set up a second straight final showdown with world number two Aryna Sabalenka.
Surprise package Davidovich Fokina, who knocked out top-ranked Novak Djokovic and Indian Wells champion Taylor Fritz in the earlier rounds at Monaco, drew first blood by breaking Tsitsipas to take a 2-1 lead in the opening set.
Rangy 19-year-old Mensik, the 2022 boy's singles finalist at Melbourne Park, sealed the match in style with a searing forehand winner to push the three-times Grand Slam finalist and sixth seed to the exit.
Novak Djokovic's outstanding serving, mighty forehand and all-court defence delivered him a ninth straight win over Stefanos Tsitsipas in their Red Group match.
Stefanos Tsitsipas believes he has proved a point to his critics ahead of Wimbledon by winning his maiden grasscourt title at the Mallorca Championships
Andy Murray may have been the forgotten man at the US Open but gave the crowd and Stefanos Tsitsipas a match to remember, forcing the third seed to grind out a 2-6, 7-6(7), 3-6, 6-3, 6-4 win on Monday and avoid the opening round shocker.
Images from Day 8 of the 2024 French Open at Roland Garros on Sunday.
Images from the men's singles action at the Wimbledon Championships on Saturday.
'The bubble makes it really tiring week by week'
World No. 2 Carlos Alcaraz defeated Tsitsipas in the 2021 US Open and in last year's Miami Masters and Barcelona Open.
Sparks flew when they met for the first time on the ATP Tour in Miami, with Medvedev confronting the Greek over his on-court conduct.
Stefanos Tsitsipas confirmed his meteoric rise into the highest echelon of men's tennis by battling back to beat Austrian Dominic Thiem 6-7(6) 6-2 7-6(4) in a compelling title duel at the ATP Finals on Sunday.
'Everyone is tense. It's the last slam of the season. Your last chance to go deep at a slam for a while.'
Greek fourth seed Stefanos Tsitsipas labelled Nick Kyrgios a "bully" with "an evil side" to his character after losing a bad-tempered Wimbledon third-round clash on Saturday.
Twice champion Iga Swiatek walloped Czech Karolina Muchova in straight sets to reach the Indian Wells quarter-finals on Tuesday.
Holder Stefanos Tsitsipas moved into the Monte Carlo Masters quarter-finals with a 7-5 7-6(1) victory over Laslo Djere
For the second time in three days at the ATP Finals, Rafael Nadal fought off one of the game's rising powers but beating Greek Stefanos Tsitsipas proved in vain as his semi-final hopes vanished on Friday.
Tallon Griekspoor staged a grand recovery, saving four match-points, before stunning top seed Daniil Medvedev 2-6, 7-6(7), 7-5 to reach the semi-finals of the Dubai Championships on Thursday.
Defending champion Stefanos Tsitsipas showed no signs of fatigue following Friday's marathon battle as he eased past German Alexander Zverev 6-4, 6-2 to reach the Monte Carlo Masters final on Saturday.
Holder Stefanos Tsitsipas moved into the Monte Carlo Masters quarter-finals with a 7-5, 7-6(1) victory over Laslo Djere on Thursday while fourth seed Casper Ruud was knocked out in straight sets by Grigor Dimitrov.
'I think it will be environmentally very beneficial. Life is such a hustle, and you never get the time to spend with your family and connect with them'
World number one Novak Djokovic has been "playing by his own rules" and has put his bid for a 21st Grand Slam title at risk by not following Australia's COVID-19 vaccination requirements, world number four Stefanos Tsitsipas said on Thursday.
The 20-year-old became the youngest semi-finalist at Melbourne Park since American Andy Roddick, also 20, at the 2003 tournament.
Tsitsipas will play 22nd-seeded Spaniard Roberto Bautista Agut for a place in the semi-finals.
'My arm has been -- I have had an issue there for quite a while now. It has gotten bigger in the last couple of weeks, so I'm just trying to protect it.'
Stefanos Tsitsipas credited his stellar comeback win against Rafa Nadal in Wednesday's Australian Open quarter-final to his peace of mind, saying he had attained a state of "nirvana" during the match despite falling back by two sets.
Still wearing a compression sleeve after a recent forearm issue, Carlos Alcaraz produced a stellar show in a rematch of the duo's 2022 encounter to firmly put himself back in the conversation as the favourite to lift the title in Paris and a third major.
'I guess I just put too much pressure on myself, aiming so high and I just have to take it step by step, not think too much about the future and be irrational'
Tsitsipas regained his composure to save a set point in the 10th game before sealing the victory in the tiebreak for his third career title.
Defending champion Stefanos Tsitsipas came out on top from a thrilling quarter-final clash with Diego Schwartzman, prevailing 6-2, 6-7(3), 6-4 on Friday to set up a meeting with Alexander Zverev at the Monte Carlo Masters.
Novak Djokovic was stunned 7-6(4), 6-2 by Matteo Berrettini in the Qatar Open first round on Tuesday as the Italian enjoyed his first win over the former world number one.